De-novo variation pipeline
This pipeline aims to discover and verify the 'de-novo' mutations
Contributors: Yurii, Kai, Morris
Other projects depending on this: no, this is an end-project
Aims and Deliverables
- Establish custom 'de-novo' discovery pipeline
- Identify and verify a number of 'de-novo' mutations
- Characterize ...
Because GvNL will do sequencing at 12x, identification of 'de-novo' variants based on simplistic Mendelian checks (see MendelianQcPipeline) is likely to lead to hundreds of thousands of variant, only few of which are truly 'de-novo'. A couple of ideas which may help solving the problem is listed in DeNovoVariationPipelineIdea.
BURNING: need to decide what line to follow and come up with realistic plan and estimate for resources needed!
Automated workflow (will be) provided in DeNovoVariationPipelineWorkflow? page.